Washington 41, Jaguars 10

LANDOVER, Md. (AP) — Robert Griffin III dislocated his left ankle and DeSean Jackson sprained his left shoulder in the first quarter, then Kirk Cousins stepped in. He completed 22 of 33 passes for 250 yards and a pair of touchdowns Sunday in Washington’s 41-10 romp past Jacksonville.

Griffin was carted to the locker room with his leg in a splint and could be out for two months. He will undergo X-rays to determine if the ankle is broken.

Cousins subbed for Griffin and completed his first 12 passes. Ryan Kerrigan had four of the Redskins’ 10 sacks, and Washington’s defense didn’t allow Jacksonville (0-2) past midfield until the final two minutes of the first half.

Washington (1-1) outgained Jacksonville 449-148.

Chargers 30, Seahawks 21

SAN DIEGO (AP) — Antonio Gates had three touchdown catches and the Chargers controlled the tempo to keep Seattle’s offense off the field.

Gates’ 21-yard catch late in the third quarter was epic, as the star tight end split two defenders and extended for Philip Rivers’ pass, reaching out with his left hand to gather it in. Flat on his back, he held up the ball to show the officials he made the catch that gave San Diego a 27-14.

Rivers was 28 of 37 for 284 yards.

San Diego (1-1) had blown an 11-point fourth-quarter lead and lost its opener Monday night at Arizona. Seattle (1-1) had nine days to prepare after a 20-point opening victory against Green Bay.

Browns 26, Saints 24

CLEVELAND (AP) — Billy Cundiff kicked a 29-yard field goal with 3 seconds left. Cundiff’s kick helped the Browns (1-1) snap a nine-game losing streak in home openers and gave rookie coach Mike Pettine his first NFL win.

Brian Hoyer drove the Browns 85 yards in 14 plays in the final 2:46 to set up Cundiff’s winner. Hoyer completed several big passes, none more crucial than his 28-yarder to Andrew Hawkins with 13 seconds to go.

The Saints (0-2) rallied from a 13-point deficit to take the lead on Mark Ingram’s 1-yard TD run with 12:12 left. Drew Brees threw two touchdown passes to Jimmy Graham and moved into fourth place on the NFL’s career passing list.

Down 24-23, Cleveland took over at its 4. Missing suspended receiver Josh Gordon and without injured Pro Bowl tight end Jordan Cameron and running back Ben Tate, Hoyer calmly took the Browns down the field.

Packers 31, Jets 24

GREEN BAY, Wis. (AP) — Aaron Rodgers threw for three touchdowns, Jordy Nelson had a career-high 209 yards receiving and the Packers rallied from an 18-point deficit.

New York appeared to tie it with 5 minutes left on a 37-yard catch by Jeremy Kerley on fourth down — but it was negated because the Jets (1-1) called a timeout from the sideline just before the snap. The Packers (1-1) held on from there to avoid their first 0-2 start since 2006.

Randall Cobb caught two short scoring strikes and a 2-point conversation that gave the Packers a 24-21 lead in the third quarter.

Green Bay (1-1) went up 31-24 late in the third quarter when Nelson worked a double move on Dee Milliner for an 80-yard touchdown catch.

Bills 29, Dolphins 10

ORCHARD PARK, N.Y. (AP) — C.J. Spiller scored on a 102-yard kickoff return, and rookie receiver Sammy Watkins had a 12-yard touchdown catch.

The Dolphins (1-1) also lost a key offseason addition when running back Knowshon Moreno did not return after hurting his left elbow 11 minutes in.

Spiller and Watkins, the Clemson connection, both scored in the third quarter, putting Buffalo (2-0) ahead 23-10.

The Bills rode the momentum of a charged-up crowd in a home opener that celebrated the franchise’s past and future. The Bills paid tribute to late owner Ralph Wilson, who died in March. On Tuesday, Wilson’s estate reached a “definitive agreement” to sell the team to Terry and Kim Pegula for an NFL-record $1.4 billion.

Patriots 30, Vikings 7

MINNEAPOLIS (AP) — Tom Brady and the Patriots took advantage of Adrian Peterson’s absence and Matt Cassel’s four interceptions.

Chandler Jones returned a field goal he blocked for a touchdown right before halftime.

Brady went 15 for 22 for 149 yards, one touchdown and no turnovers, and Cassel’s first start against his close friend and former mentor was a dud. Devin McCourty, Darrelle Revis, Logan Ryan and Dominique Easley all picked him off, setting up 17 points for the Patriots, prompting “Teddy! Teddy! Teddy!” chants from the crowd for the rookie Bridgewater.

Peterson was shelved for the game after a charge of child abuse was levied against him Friday in Texas.

Broncos 24, Chiefs 17

DENVER (AP) — Terrance Knighton batted away Alex Smith’s fourth-and-goal pass to Dwayne Bowe with 15 seconds left.

The Broncos (2-0) thought they had sealed the win twice earlier on the drive. Aqib Talib’s interception return for a touchdown was negated by Quanterus Smith’s hold. Then Nate Irving’s fumble recovery following DeMarcus Ware’s sack and strip was ruled an incomplete pass after a replay.

The Chiefs (0-2) converted 11 of 16 third-down opportunities overall. They just couldn’t capitalize in the biggest moments as the Broncos mustered two goal-line stands for the second straight week.

Peyton Manning was 21 of 26 for 242 yards and three TDs.

Cowboys 26, Titans 10

NASHVILLE, Tenn. (AP) — DeMarco Murray ran for 167 yards and a touchdown and Dan Bailey kicked four field goals. The loss spoiled Tennessee first-year coach Ken Whisenhunt’s home debut.

Dallas (1-1) scored the first 16 points of the game in the first half.

Even the beleaguered Dallas defense got into the act, coming up with two sacks and two interceptions.

Tony Romo easily shook off his three interceptions in the season-opening loss to San Francisco. With Murray running so well, Romo was 19 of 29 for 176 yards and a TD.

The Titans (1-1) struggled in all areas after winning their opener.

Texans 30, Raiders 14

OAKLAND, Calif. (AP) — J.J. Watt caught a 1-yard touchdown pass, Arian Foster ran for 138 yards and a score and the Texans won their second straight game.

Instead of controlling the game from his usual defensive end position, Watt made his biggest impact on the opening drive when he lined up as a tight end. He caught a pass from Ryan Fitzpatrick to get Houston (2-0) started.

After losing their final 14 games in a two-win season in 2013, the Texans have opened strong under new coach Bill O’Brien.

The home opener for the Raiders (0-2) hardly could have gone worse as they fell behind 27-0 after three quarters.

Cardinals 25, Giants 14

EAST RUTHERFORD, N.J. (AP) — Ted Ginn Jr. ran 71 yards on a punt return for a go-ahead fourth-quarter touchdown.

Playing in a regular-season game for the first time since 2010, Drew Stanton replaced the scratched Carson Palmer and led the Cardinals (2-0) on three long scoring drives. Arizona won for the ninth time in 11 games.

Jonathan Dwyer scored on a 1-yard run and Chandler Catanzaro kicked four field goals, including one a minute after Ginn’s electrifying return on which the speedster bounced off a tackle and was gone.

The Cardinals got the ball back right away after Quintin Demps fumbled on the ensuing kickoff return.

Eli Manning threw two touchdowns for the Giants (0-2), who turned over the ball four times.